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Iprex

Iprex

Metered-Dose Inhaler (MDI)

🧬 Ipratropium Bromide 🏢 Square Pharmaceuticals PLC
Generic Name Ipratropium Bromide
Strength 20 mcg/puff
Manufacturer Square Pharmaceuticals PLC
Unit Price 200 metered doses: ৳ 250.00

🔹 Indications

🔹 Dosage & Administration

Nebuliser Solution-

Adults (including the elderly) and children over 12 years of age: 250-500 micrograms (i.e. 1 ml or 2 ml) 3 to 4 times daily.

For treatment of acute bronchospasm: 500 micrograms/2 ml. It is advisable not to exceed the recommended daily dose during either acute or maintenance treatment. Daily doses exceeding 2 mg in adults and children over 12 years of age should only be given under medical supervision.

Children 6-12 years of age: 250 micrograms (i.e. 1 ml) up to a total daily dose of 1 mg (4 ml). The time interval between doses may be determined by the physician.

Children 0-5 years of age (for treatment of acute asthma only): 125-250 micrograms (i.e. 0.5 ml-1 ml) up to a total daily dose of 1 mg (4 ml). Ipratropium bromide should be administered no more frequently than 6 hourly in children under 5 years of age. Repeated doses can be administered until the patient is stable. The time interval between the doses may be determined by the physician.

Ipratropium Nebuliser Solution may be combined with a short-acting beta 2-agonist in the same nebulizer chamber. The solution should be used as soon as possible after mixing and any unused solution should be discarded. Ipratropium Nebuliser Solution can be administered using a range of commercially available nebulizing devices. The dose of nebulizer solution may need to be diluted in order to obtain a final volume suitable for the particular nebulizer being used (usually 2-4 ml); if dilution is necessary use only sterile sodium chloride 0.9% solution. The unit dose Ipratropium Nebulizer Solution is intended only for inhalation with suitable nebulizing devices and should not be taken orally or administered parenterally.


Inhaler-

Adults: The usual dose is 1-2 puffs (20 gm/spray) three or four times daily. Single dose upto 80 gm (4 puffs) may be required to obtain maximum benefit during early treatment. Patients may take additional inhalations as required; however, the total number of inhalations should not exceed 12 in 24 hours.

Children:
  • 6-12 years: Usually 1-2 puffs two to three times daily.
  • Below 6 years: The usual dose is 1 puff (20 gm) three times daily.
  • In order to ensure that the inhaler is used correctly, the administration should be supervised by an adult.
  • No specific information on the use of the product in the elderly is available. Clinical trials have included patients over 65 years and no adverse reactions specific to this age group has been reported.

🔹 Interaction

Inhaler: Iprex has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, steroids and cromolyn sodium, commonly used in the treatment of chronic obstructive pulmonary disease, without adverse drug reactions. There are no studies fully evaluating the  interaction effects of Iprex and these drugs with respect to effectiveness.

🔹 Contraindications

Nebuliser Solution: Known hypersensitivity to atropine or its derivatives, or to any other component of the product.

Inhaler: Known hypersensitivity to Ipratropium, Atropine or its derivative. Also contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean, lecithin and peanut.

🔹 Side Effects

Nebuliser Solution:
  • Common: Headache, Dizziness, Cough, Inhalation induced bronchospasm, Dryness of mouth, Vomiting.
  • Uncommon: Urticaria, Tachycardia, Skin rash, Pruritus. Rare: Anaphylactic reaction, Eye pain, Mydriasis, Intraocular pressure increased, Palpitations, Atrial fibrillation, Nausea.
Inhaler:
  • Potentially life-threatening effects- Idiosyncratic reactions to Iprex are rare. Severe adverse effects due to the inhibition of muscarinic receptors and ganglion blockade are theoretically possible but unlikely with the metered-dose aerosol.
  • Severe/Irreversible adverse effects- No effects of this kind is reported.
  • Symptomatic adverse effects- Regular use of Iprex can lead to a dry mouth through inhibition of salivary low.
  • Observed during clinical practice- The most common adverse reactions reported are dryness of the oropharynx (5%); cough, exacerbation of symptoms, & irritation from aerosol (3%); headache (2%); nausea, dizziness, blurred vision/difficulty in accommodation & drying of secretions (1%). Less frequently reported adverse reactions to include tachycardia, nervousness, paresthesias, drowsiness, coordination difficulty, itching, hives, flushing, alopecia, constipation, tremor & mucosal ulceration. Case of precipitation or worsening of narrow-angle glaucoma, acute eye pain & hypotension have been reported. Allergic-type reactions such as skin rash, angioedema of the tongue, lips & face, urticaria (including giant urticaria), laryngospasm and anaphylactic reactions have been also reported; with positive rechallenges in some cases. Iprex does not produce adverse effects on mucociliary clearance, in contrast to atropine and other muscarinic antagonists. There is no evidence that in the therapeutic dose range, Iprex has any adverse effect on bronchial secretion.

🔹 Pregnancy & Lactation

The safety of Ipratropium Nebulizer Solution during human pregnancy has not been established. The benefits of using Ipratropium Nebuliser Solution during pregnancy must be weighed against the possible hazards to the fetus. It is not known whether ipratropium bromide is excreted into breast milk. Caution should be exercised when Ipratropium Nebulizer Solution is administered to nursing mothers.

🔹 Precautions & Warnings

Nebuliser Solution: Use of the nebulizer solution should be subject to close medical supervision during initial dosing. Caution is advocated in the use of anticholinergic agents in patients with narrow-angle glaucoma, or with prostatic hyperplasia or bladder-outflow obstruction or cystic fibrosis. Immediate hypersensitivity reactions have been demonstrated by rare cases of urticaria, angioedema, rash, bronchospasm, oropharyngeal edema and anaphylaxis. There have been isolated reports of ocular complications (i.e. mydriasis, increased intraocular pressure, narrow-angle glaucoma, eye pain) when aerosolized Iprex has come into contact with the eyes during nebulizer therapy.
  • Patients must be instructed in the correct administration of the Iprex Nebulizer Solution.
  • Care must be taken not to allow the solution or mist to enter the eyes.
  • It is recommended that the nebulizer solution is administered via a mouthpiece.
  • If a mouthpiece is not available and a nebulizer mask is used, it must fit properly.
Inhaler: Patients should be advised that temporary blurring of vision precipitation or worsening of narrow-angle glaucoma or eye pain may result if the aerosol is sprayed into the eyes. If recommended dosage does not provide relief or symptoms become worse, patients should seek immediate medical attention. While taking
Iprex inhalation aerosol, other inhaled drugs should not be used unless prescribed.

Iprex inhalation aerosol is not indicated for the initial treatment of acute episodes of bronchospasm where rapid response is required. Drugs with faster onset may be preferable as initial therapy in this situation. Immediate hypersensitivity reactions may occur after administration of Iprex, as demonstrated by rare cases of urticaria, angio-oedema, rash, bronchospasm and oropharyngeal oedema.

🔹 Storage Conditions

As the product contains no preservative, a fresh ampoule should be used for each dose and the ampoule should be opened immediately before administration. Any solution left in the ampoule should be discarded. Do not store above 25°C. Keep the ampoule in the outer carton.

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💡 Frequently Asked Questions

Nebuliser Solution: It is indicated for the treatment of reversible bronchospasm associated with chronic obstructive pulmonary disease (COPD). It is also indicated, when used concomitantly with inhaled beta 2-agonists, for treatment of reversible air...
Nebuliser Solution- Adults (including the elderly) and children over 12 years of age: 250-500 micrograms (i.e. 1 ml or 2 ml) 3 to 4 times daily.For treatment of acute bronchospasm: 500 micrograms/2 ml. It is advisable not to exceed the recommended d...
Nebuliser Solution: Common: Headache, Dizziness, Cough, Inhalation induced bronchospasm, Dryness of mouth, Vomiting. Uncommon: Urticaria, Tachycardia, Skin rash, Pruritus. Rare: Anaphylactic reaction, Eye pain, Mydriasis, Intraocular pressure inc...

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